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2′,5′-Dideoxyadenosine

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Adenylate cyclase inhibitor

A useful, cell-permeable inhibitor of adenylate cyclase (ID₅₀=250µM). Inhibits growth and causes cell differentiation (1.5µM) in K562 cells.

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Appearance	White to off-white solid.
CAS	6698-26-6
Couple Target	Adenylate cyclase
Couple Type	Inhibitor
Formula	C₁₀H₁₃N₅O₂
MW	235.2
Purity	≥98% (HPLC)
Solubility	Soluble in water (20mg/ml at 50°C) or DMSO (30mg/ml).

Use/Stability	As indicated on product label or CoA when stored as recommended. Solutions are stable up to 3 months when stored at -20°C
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Erythroid differentiation and growth inhibition of K562 cells by 2’,5’-dideoxyadenosine: synergism with interferon-alpha: K. Ogawa et al.; Leuk. Res. 19, 749 (1995), Abstract
Direct inhibitory effect of neurotensin on isolated gastric smooth muscle cells of guinea pig via the cyclic GMP system: Y. Chijiiwa et al.; Digestion 54, 135 (1993), Abstract
Isoproterenol antagonistic effect of 2’,5’-dideoxyadenosine in the isolated perfused guinea-pig heart: M. Hartmann & J. Schrader; J. Mol. Cell. Cardiol. 25, 331 (1993), Abstract
: I. BAggioni; Am. J. Hypertens. 6, 1475 (1992)
Inhibition of adenylate cyclase attenuates adenosine receptor-mediated relaxation in coronary artery: M.H. Sabouni et al.; J. Pharmacol. Exp. Ther. 259, 508 (1991), Abstract
Role of adenylate cyclase in immunologic release of mediators from rat mast cells: agonist and antagonist effects of purine- and ribose-modified adenosine analogs: S.T. Holgate et al.; PNAS 77, 6800 (1980), Abstract

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