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24(S),25-Epoxycholesterol

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LXR ligand

Endogenous agonist for the nuclear receptor LXR.

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Appearance	White solid.
CAS	77058-74-3
Couple Target	LXR
Couple Type	Ligand
Formula	C₂₇H₄₄O₂
Identity	Determined by NMR.
MW	400.6
MeltingPoint	156-159°C
Purity	≥98% (TLC)
Solubility	Soluble in ethanol (10mg/ml) or DMSO (10mg/ml – requires warming to ~40°C which has been shown to lead to significant decomposition of the product).

Use/Stability	As indicated on product label or CoA when stored as recommended. Product should be used immediately following dissolution.
Handling	Store with desiccant. Product packaged under inert gas.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

LXR alters CD4sup>+/sup> T cell function through direct regulation of glycosphingolipid synthesis: Waddington, K. E., Robinson, G. A., et al.; bioRxiv , (2019)
Chemical regulators of epithelial plasticity reveal a nuclear receptor pathway controlling myofibroblast differentiation: J.M. Carthy, et al.; Sci. Rep. 6, 29868 (2016), Application(s): Screening of chemical compounds with HaCaT cells, Abstract — Full Text
Nuclear receptors and lipid physiology: opening the X-files: A. Chawla, et al.; Science 294, 1866 (2001), Abstract

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