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20-Hydroxy-leukotriene B4

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Primary LTB₄ metabolite produced by ω oxidation in PMNL retaining some chemotactic activity. ω oxidation is blocked by 17-ODYA.

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Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-80°C
Shipping	Dry Ice

Regulatory Status	RUO – Research Use Only

Identification and functional characterization of leukotriene B4 20-hydroxylase of human polymorphonuclear leukocytes: R. J. Soberman, et al.; Proc. Natl. Acad. Sci. USA 82, 2292 (1985), Abstract — Full Text
Omega-oxidation is the major pathway for the catabolism of leukotriene B4 in human polymorphonuclear leukocytes: S. Shak, et al.; J. Biol. Chem. 259, 10181 (1984), Abstract — Full Text
Properties of leukotriene B4 20-hydroxylase from polymorphonuclear leukocytes: W. S. Powell, et al.; J. Biol. Chem. 259, 3082 (1984), Abstract — Full Text
Stereospecificity of leukotriene B4 and structure-function relationships for chemotaxis of human neutrophils: C. A. Dahinden, et al.; J. Immunol. 133, 1477 (1984), Abstract

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