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Cannabinoid receptor ligand
Endogenous ligand for the CB1 receptor (CB1: Ki=58.3nM); CB2: Ki>3µM) present in high levels in the CNS.
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Product Details
| Alternative Name |
2-AG |
|---|---|
| Appearance |
Oil. |
| CAS |
53847-30-6 |
| Couple Target |
Cannabinoid receptor |
| Couple Type |
Ligand |
| Formula |
C23H38O4 |
| Identity |
Determined by IR. |
| MW |
378.6 |
| Purity |
≥98% (TLC) |
| Solubility |
Soluble in DMSO or 100% ethanol. |
Handling & Storage
| Use/Stability |
As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored, as supplied, at -70°C. Stock solutions are stable for up to 3 months when stored at -70°C under an atmosphere of nitrogen or argon. |
|---|---|
| Handling |
Protect from light and oxygen. Keep under inert gas. |
| Long Term Storage |
-80°C |
| Shipping |
Dry Ice |
| Regulatory Status |
RUO – Research Use Only |
|---|
- Palmitoylethanolamide counteracts substance P-induced mast cell activation in vitro by stimulating diacylglycerol lipase activity: S. Petrosino, et al.; J. Neuroinflammation 16, 274 (2019), Abstract — Full Text
- Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus: J.K. Makara, et al.; Nat. Neurosci. 8, 1139 (2005), Abstract
- A new class of inhibitors of 2-arachidonoylglycerol hydrolysis and invasion of prostate cancer cells: K. Nithipatikom, et al.; BBRC 332, 1028 (2005), Abstract
- 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, induces rapid actin polymerization in HL-60 cells differentiated into macrophage-like cells: M. Gokoh, et al.; Biochem. J. 386, 583 (2005), Abstract — Full Text
- 2-arachidonoylglycerol: a novel inhibitor of androgen-independent prostate cancer cell invasion: K. Nithipatikom, et al.; Cancer Res. 64, 8826 (2004), Abstract — Full Text
- New perspectives in the studies on endocannabinoid and cannabis: 2-arachidonoylglycerol as a possible novel mediator of inflammation: T. Sugiura, et al.; J. Pharmacol. Sci. 96, 367 (2004), Abstract — Full Text
- The endogenous cannabinoid 2-arachidonoyl glycerol as in vivo chemoattractant for dendritic cells and adjuvant for Th1 response to a soluble protein: G.J. Maestroni; FASEB J. 18, 1914 (2004), Abstract — Full Text
- 2-Arachidonoylglycerol, an endogenous cannabinoid receptor ligand, induces accelerated production of chemokines in HL-60 cells: S. Kishimoto, et al.; J. Biochem. 135, 517 (2004), Abstract
- Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain: T. Bisogno, et al.; J. Cell Biol. 163, 463 (2003), Abstract
- The uptake by cells of 2-arachidonoylglycerol, an endogenous agonist of cannabinoid receptors: T. Bisogno, et al.; Eur. J. Biochem. 268, 1982 (2001), Abstract
- Evidence that the cannabinoid CB1 receptor is a 2-arachidonoylglycerol receptor. Structure-activity relationship of 2-arachidonoylglycerol, ether-linked analogues, and related compounds: T. Sugiura, et al.; J. Biol. Chem. 274, 2794 (1999), Abstract — Full Text
- Metabolism of anandamide and 2-arachidonoylglycerol: an historical overview and some recent developments: V. Di Marzo, et al.; Lipids 34, S319 (1999), (Review), Abstract
- Enzymes of porcine brain hydrolyzing 2-arachidonoylglycerol, an endogenous ligand of cannabinoid receptors: S.K. Goparaju, et al.; Biochem. Pharmacol. 57, 417 (1999), Abstract
- An entourage effect: inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabinoid activity: S. Ben-Shabat, et al.; J. Pharmacol. 353, 23 (1998), Abstract
- 2-Arachidonoylglycerol, an endogenous cannabinoid receptor agonist: identification as one of the major species of monoacylglycerols in various rat tissues, and evidence for its generation through CA2+-dependent and -independent mechanis: S. Kondo, et al.; FEBS Lett. 429, 152 (1998), Abstract
- A second endogenous cannabinoid that modulates long-term potentiation: N. Stella, et al.; Nature 388, 773 (1997), Abstract
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