1G244

• GMP format available

1G244 is a potent inhibitor of dipeptidyl peptidase 8 (DPP8) and dipeptidyl peptidase 9 (DPP9), with IC50 values of 14 nM and 53 nM, respectively.

Key features and applications include:

• High Selectivity: Specifically inhibits DPP8 and DPP9 without affecting DPPIV and DPPII.
• Potency: Demonstrates strong inhibitory effects with low IC50 values.
• Induce Apoptosis: Promotes apoptosis in multiple myeloma cells, exhibiting anti-myeloma effects.
• Inhibit Adipogenesis: Blocks adipogenesis in preadipocyte cell lines.
• Suppress Tumor Growth: Reduces subcutaneous tumor growth in murine xenograft models.

Relevant disease states include:

• Multiple Myeloma: Induces apoptosis in multiple myeloma cells, making it a valuable tool for studying this cancer.
• Atherosclerosis: Exhibits antiatherosclerotic properties by inhibiting DPP8/9.
• Inflammatory Diseases: Inhibition of DPP8/9 by 1G244 has been shown to cause pro-caspase-1-dependent pyroptosis in macrophages and monocytes.