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17-Octadecynoic acid

BML-EI103

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Fatty acid ω-hydroxylase inhibitor

Potent suicide inhibitor of LTB₄ ω-oxidase (IC₅₀<5µM). Potent and selective inhibitor of fatty acid ω-hydroxylase (IC₅₀<100 nM). Blocks biosynthesis of 20-HETE.

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Product Details

Appearance	White solid.
CAS	34450-18-5
Couple Target	Fatty acid omega-hydroxylase, Leukotriene oxidase
Couple Type	Inhibitor
Formula	C₁₈H₃₂O₂
MW	280.5
MeltingPoint	67-68°C
Purity	≥98% (HPLC)
Solubility	Soluble in ethanol (25mg/ml) or DMSO (25mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Endogenously generated arachidonate-derived ligands for TRPV1 induce cardiac protection in sepsis: J. Chan, et al.; FASEB J. 32, 3816 (2018), Application(s): Inhibition of 20-HETE biosynthesis in mice, Abstract
Effects of 17-octadecynoic acid, a suicide-substrate inhibitor of cytochrome P450 fatty acid omega-hydroxylase, on renal function in rats: A.-P. Zou, et al.; J. Pharmacol. Exp. Ther. 268, 474 (1994), Abstract
Leukotriene B4 omega-hydroxylase in human polymorphonuclear leukocytes. Suicidal inactivation by acetylenic fatty acids: S. Shak, et al.; J. Biol. Chem. 260, 13023 (1985), Abstract — Full Text

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17-Octadecynoic acid

BML-EI103

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

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