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Alvespimycin hydrochloride (17-DMAG HCl) is a cell permeable potent HSP90 inhibitor with IC50 of 62 nM in a cell-free assay. 17-DMAG HCl is a geldanamycin analog that displays superior pharmacological properties and induces apoptosis in a variety of tumor cell lines. 17-DMAG HCl also inhibits angiogenesis.
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