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17-AAG

LSI-AC-2005

Axxora Marketplace
  • LSI-AC-2005-0005   —   5 mg
    $255.00

Tanespimycin (17-AAG) is a cell permeable, less toxic and more stable semi-synthetic analog of geldanamycin. 17-AAG is a potent HSP90 inhibitor displaying a 100-fold higher affinity for tumor cell derived HSP90 over normal cell HSP90. 17-AAG displays anti-angiogenic activity and sensitizes tumor cells to apoptosis in response to such agents as taxol and cisplatin. Tanespimycin (17-AAG) depletes cellular STK38/NDR1 and reduces STK38 kinase activity. Tanespimycin (17-AAG) also downregulates stk38 gene expression.

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Regulatory Status

RUO – Research Use Only