Home Shop 15(S)-Hydroxyeicosa-5Z,8Z,11Z,13E-tetraenoic acid (HETE)

15(S)-Hydroxyeicosa-5Z,8Z,11Z,13E-tetraenoic acid (HETE)

BML-H015

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Ultra-pure

Biosynthesis in human neutrophils, eosinophils and reticulocytes. Most abundant eicosanoid in human bronchi. Regulates T lymphocyte mitogenesis. Induces immunosupression. Stimulates migration of capillary endothelial cells and neovascularization.

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Product Details

Alternative Name	15(S)-HETE
Appearance	Liquid.
CAS	54845-95-3
Formulation	Oil dissolved in ethanol.
MW	320.5
Purity	≥99% (HPLC)
Source	Synthetic.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-80°C
Shipping	Dry Ice

Regulatory Status	RUO – Research Use Only

Profiling oxylipins released from human platelets activated through the GPVI collagen receptor: R.E. Turnbull, et al.; Prostaglandins Other Lipid Mediat. 158, 106607 (2022), Abstract
Programming of macrophages by UV-irradiated apoptotic cancer cells inhibits cancer progression and lung metastasis: Y.B. Kim, et al.; Cell. Mol. Immunol. 16, 851 (2019), Abstract
15-Hydroxyeicosatetraenoic acid stimulates migration of human retinal microvessel endothelium in vitro and neovascularization in vivo: J. E. Graeber, et al.; Prostaglandins 39, 665 (1990), Abstract
The inhibitory role of 12- and 15-lipoxygenase products on renin release: I. Antonipillai, et al.; Hypertension 10, 61 (1987), Abstract — Full Text
Adrenal synthesis of corticosterone in response to ACTH in rats is influenced by leukotriene A4 and by lipoxygenase intermediates: D. B. Jones, et al.; J. Endocrinol. 112, 253 (1987), Abstract
Immunosuppression induced in vivo by 15 hydroxyeicosatetraenoic acid (15 HETE): J. C. Aldiger, et al.; Prostaglandins Leukot. Med. 13, 99 (1984), Abstract
Inhibition of leukotriene biosynthesis by the leukocyte product 15-hydroxy-5,8,11,13-eicosatetraenoic acid: J. Y. Vanderhoek, et al.; J. Biol. Chem. 255, 10064 (1980), Abstract — Full Text
15-hydroxy-5,8,11,13-eicosatetraenoic acid: A potent and selective inhibitor of platelet lipoxygenase: J. Y. Vanderhoek, et al.; J. Biol. Chem. 255, 5996 (1980), Abstract — Full Text

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15(S)-Hydroxyeicosa-5Z,8Z,11Z,13E-tetraenoic acid (HETE)

BML-H015

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

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