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1,5-Isoquinolinediol

BML-AP102

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PARP inhibitor

Potent inhibitor of inducible nitric oxide synthase (iNOS; NOS II) in mouse macrophages. Potent and selective PARP inhibitor. Inhibits nitric oxide (SIN-1) induced PARP activation in rat hepatocytes (at 20µM). Neuroprotectant.

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Product Details

Appearance	Yellow solid.
CAS	5154-02-9
Couple Target	PARP
Couple Type	Inhibitor
Formula	C₉H₇NO₂
MW	161.2
Purity	≥98% (HPLC)
Solubility	Soluble in DMSO (25mg/ml), dimethyl formamide (25mg/ml) or 100% ethanol (25mg/ml warm). Also soluble in 0.1N NaOH or in methanol; insoluble in water and 0.1N HCl.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Heterozygous PALB2 c.1592delT mutation channels DNA double-strand break repair into error-prone pathways in breast cancer patients: K. Obermeier, et al.; Oncogene 35, 3796 (2016), Abstract
Disrupted ADP-ribose metabolism with nuclear Poly (ADP-ribose) accumulation leads to different cell death pathways in presence of hydrogen peroxide in procyclic Trypanosoma brucei: M. Schlesinger, et al.; Parasit. Vectors 9, 173 (2016), Application(s): Potency of inhibitors, Abstract — Full Text
Substrate-assisted catalysis by PARP10 limits its activity to mono-ADP-ribosylation: H. Kleine, et al.; Mol. Cell 32, 57 (2008), Abstract
Inhibition of NOS-2 induction in LPS-stimulated J774.2 cells by 1, 5-isoquinolinediol, an inhibitor of PARP: R. Olszanecki, et al.; J. Physiol. Pharmacol. 57, 109 (2006), Abstract
All trans retinoic acid induces apoptosis in acute promyelocytic NB4 cells when combined with isoquinolinediol, a poly(ADP-ribose) polymerase inhibitor: D.M. Berry, et al.; Leuk. Res. 24, 307 (2000), Abstract
Effects of inhibitors of the activity of poly (ADP-ribose) synthetase on the organ injury and dysfunction caused by haemorrhagic shock: M.C. McDonald, et al.; Br. J. Pharmacol. 128, 1339 (1999), Abstract
Inhibition of poly(ADP-ribose)polymerase stimulates extrachromosomal homologous recombination in mouse Ltk-fibroblasts: A. Semionov, et al.; Nucleic Acids Res. 27, 4526 (1999), Abstract
Nitric oxide inhibits DNA synthesis and induces activation of poly(ADP-ribose) polymerase in cultured rat hepatocytes: M. Dalmau, et al.; Exp. Cell Res. 228, 14 (1996), Abstract
Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity: J. Zhang, et al.; Science 263, 687 (1994), Abstract
Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferase: M. Banasik, et al.; J. Biol. Chem. 267, 1569 (1992), Abstract

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1,5-Isoquinolinediol

BML-AP102

Product Details

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Datasheet, Manuals, SDS & CofA

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