Home Shop 15-Deoxy-Δ12,14-prostaglandin J2

15-Deoxy-Δ12,14-prostaglandin J2

BML-PG050

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PPARγ ligand

Prostaglandin D2 derived nuclear peroxisome proliferator-activated receptor γ (PPARγ) ligand. Induces apoptosis in a number of cell types including human lung cancer cells, synoviocytes and macrophages. Promotes differentiation of fibroblasts to adipocytes. Antiinflammatory activity. Inhibits angiogenesis. Prevents TNFα induced leptin increase in mice. TRPA1 agonist. Serious doubts as to the biological relevance of this prostaglandin have been raised. Endogenous levels seem to be too low to have any effect as a PPARγ ligand.

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Product Details

Alternative Name	15-deoxy-Δ12,14-PGJ2
Appearance	Neat oil. Vials may appear empty because the oil tends to coat the inside of the vial.
CAS	87893-55-8
Couple Target	PPAR, TRP channel
Couple Type	Ligand
Formula	C₂₀H₂₈O₃
MW	316.5
Purity	≥97% (TLC)
Solubility	Soluble in 100% ethanol (25mg/ml) or DMSO (25mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Handling	It is recommended to add an appropriate solvent directly to the vial.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

PPARγ regulates the expression of genes involved in the DNA damage response in an inflamed endometrium: K. Mierzejewski, et al.; Sci. Rep. 12, 4026 (2022), Abstract
A comparative study of small molecules targeting eIF4A: S.K. Naineni, et al.; RNA 26, 541 (2020), Abstract — Full Text
Programming of macrophages by UV-irradiated apoptotic cancer cells inhibits cancer progression and lung metastasis: Y.B. Kim, et al.; Cell. Mol. Immunol. 16, 851 (2019), Abstract
Implications of a genetically determined nitric oxide deficit for endothelial cell-leukocyte interaction and cardiovascular disease: I. Kadiyska; , (2016), (PhD thesis); Application(s): Cell treatment, differentiated Th1 cells, Full Text
Transient receptor potential ankyrin 1 receptor activation in vitro and in vivo by pro-tussive agents: GRC 17536 as a promising anti-tussive therapeutic: Mukhopadhyay, I., Kulkarni, A., et al.; PLoS One 9, e97005 (2014), Abstract
Activation of TRPA1 by farnesyl thiosalicylic acid: M. Maher, et al.; Mol. Pharmacol. 73, 1225 (2008), Abstract
15-Deoxy-delta12,14-PGJ2: endogenous PPARgamma ligand or minor eicosanoid degradation product?: W.S. Powell; J. Clin. Invest. 112, 828 (2003), Abstract
Anti-inflammatory agents inhibit the induction of leptin by tumor necrosis factor-alpha: B.N. Finck & R.W. Johnson; Am. J. Physiol. Regul. Integr. Comp. Physiol. 282, R1429 (2002), Abstract
Delayed activation of PPARgamma by LPS and IFN-gamma attenuates the oxidative burst in macrophages: A.A. Von Knethen, et al.; FASEB J. 15, 535 (2001), Abstract
15-deoxy-delta(12,14)-PGJ(2) induces synoviocyte apoptosis and suppresses adjuvant-induced arthritis in rats: Y. Kawahito, et al.; J. Clin. Invest. 106, 189 (2000), Abstract

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15-Deoxy-Δ12,14-prostaglandin J2

BML-PG050

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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