14-3-3β (human), (recombinant) (His-tag)

14-3-3 proteins are dimeric phosphoserine/phosphothreonine binding proteins, which have been shown to be involved in the regulation of many crucial processes such as signal transduction, cell-cycle control, apoptosis, protein localization, phosphorylation state and stability, transcription, metabolism, and malignant transformation. Binding of 14-3-3β to histone deacetylases 4 and 5 prevents their nuclear localization. 14-3-3β has also been shown to be associated with 3-repeat tau neurofibrillary tangles in Alzheimer’s disease.