14-3-3η (human), (recombinant) (His-tag)

14-3-3 proteins are dimeric phosphoserine/phosphothreonine binding proteins, which have been shown to be involved in the regulation of many crucial processes such as signal transduction, cell-cycle control, apoptosis, protein localization, phosphorylation state and stability, transcription, metabolism, and malignant transformation. The expression of 14-3-3η was reported to be significantly reduced in the cerebella of transgenic mice overexpressing IGF-1 and was predominantly, if not exclusively, expressed in Purkinje cells. It has also been reported that 14-3-3η functions as a positive regulator in the glucocorticoid signal pathway.