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13(S)-Hydroxyoctadeca-9Z,11E-dienoic acid

BML-HO013

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Inhibits thromboxane production in human platelets

Biosynthesis in rabbit peritoneal serous membranes, atherosclerotic plaques, healthy blood vessels, psoriatic skin, endothelial cells. Stimulates prostacyclin production by endothelial cells. Inhibits thromboxane production in human platelets. Inhibits platelet and tumor cell adhesion to endothelium. Antagonizes 12-HETE-induced tumor cell adhesion to endothelium. Stimulates DNA synthesis in BALB/c 3T3 fibroblasts.

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Product Details

Alternative Name	13(S)-HODE
Appearance	Clear to light-yellow liquid.
CAS	29623-28-7
Formula	C₁₈H₃₂O₃
Formulation	Solution in ethanol.
MW	296.5
Purity	≥99% (HPLC)
Source	Synthetic.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-80°C
Shipping	Dry Ice

Regulatory Status	RUO – Research Use Only

Regulation of tumor cell adhesion by intracellular 13-HODE: 15-HETE ratio: E. Bastida, et al.; J. Lipid Mediators 2, 281 (1990), Abstract
Cyclic AMP regulation of endothelial cell triacylglycerol turnover, 13-hydroxyoctadecadienoic acid (13-HODE) synthesis and endothelial cell thrombogenicity: T. A. Haas, et al.; Biochim. Biophys. Acta 1051, 174 (1990), Abstract
Epidermal growth factor stimulates linoleic acid metabolism in BALB/c 3T3 fibroblasts: W.C. Glasgow & T.E. Eling; Mol. Pharmacol. 38, 503 (1990), Abstract
Bidirectional control of membrane expression and/or activation of the tumor cell IRGpIIb/IIIa receptor and tumor cell adhesion by lipoxygenase products of arachidonic acid and linoleic acid: I.M. Grossi, et al.; Cancer Res. 49, 1029 (1989), Abstract — Full Text
13-Hydroxyoctadecadienoic acid (13-HODE) stimulates prostacyclin production by endothelial cells: B.N.Y. Setty, et al.; Biochem. Biophys. Res. Commun. 146, 502 (1987), Abstract
13-Hydroxyoctadeca-9,11-dienoic acid (13-HODE) inhibits thromboxane A2 synthesis, and stimulates 12-HETE production in human platelets: B.N.Y. Setty, et al.; Biochem. Biophys. Res. Commun. 148, 528 (1987), Abstract
13-Hydroxyoctadecadienoic acid is the vessel wall chemorepellant factor, LOX: M.R. Buchanan, et al.; J. Biol. Chem. 260, 16056 (1985), Abstract — Full Text

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13(S)-Hydroxyoctadeca-9Z,11E-dienoic acid

BML-HO013

Product Details

Handling & Storage

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