Home Shop 12(S)-Hydroxyeicosa-5Z,8Z,10E,14Z-tetraenoic acid (HETE)

12(S)-Hydroxyeicosa-5Z,8Z,10E,14Z-tetraenoic acid (HETE)

BML-H012

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Biosynthesis by platelet 12-lipoxygenase. Chemotactic and chemokinetic for PMNL²and for vascular smooth muscle cells. Antiproliferative effect on smooth muscle cells. Second messenger in angiotensin induced aldosterone production. Induces endothelial cell retraction and tumor cell adhesion.

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Product Details

Alternative Name	12(S)-HETE
Appearance	Liquid.
CAS	54397-83-0
Formula	C₂₀H₃₂O₃
Formulation	Liquid. Solution in ethanol.
MW	320.5
Purity	≥98% (HPLC)

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-80°C
Shipping	Dry Ice

Regulatory Status	RUO – Research Use Only

Feed‑back loops integrating RELA, SOX18 and FAK mediate the break‑down of the lymph‑endothelial barrier that is triggered by 12(S)‑HETE: Engleitner, S., Milovanovic, D., et al.; Int. J. Oncol. 56, 1034 (2020), Abstract

Last modified: May 29, 2024

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12(S)-Hydroxyeicosa-5Z,8Z,10E,14Z-tetraenoic acid (HETE)

BML-H012

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

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