Home Shop 12(S)-Hydroperoxyeicosa-5Z,8Z,10E,14Z-tetraenoic acid (HPETE)

12(S)-Hydroperoxyeicosa-5Z,8Z,10E,14Z-tetraenoic acid (HPETE)

BML-HP012

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Thromboxane synthase inhibitor

Primary metabolite of arachidonic acid via the 12-lipoxygenase pathway. Inhibits thromboxane synthase. Inhibits platelet aggregation via activation of guanylate cyclase (100% at 5µM). Stimulates leukotriene biosynthesis. Potent and selective inhibitor of Ca²⁺-calmodulin-dependent protein kinase II (IC₅₀=0.7µM). Endogenous TRPV1 agonist (K_i=0.35µM).

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Product Details

Alternative Name	12(S)-HPETE
Appearance	Liquid.
CAS	71774-10-2
Couple Target	CaM kinase, Guanylyl cyclase, Thromboxane synthase, TRP channel
Couple Type	Inhibitor, Ligand
Formula	C₂₀H₃₂O₄
Formulation	Solution in ethanol.
MW	336.5
Purity	≥98%
Solubility	Soluble in DMSO or dimethyl formamide; slightly soluble in PBS, pH 7.2 (0.8mg/ml) or 0.1M Na2CO3 (2mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 6 months after receipt when stored at -80°C. Product is highly unstable in aqueous solution. We recommend using aqueous solutions within fifteen minutes.For experiments with cells or tissues, aliquots of ethanol solutions may be added
Handling	After opening, prepare aliquots and store at -80°C.
Long Term Storage	-80°C
Shipping	Dry Ice

Regulatory Status	RUO – Research Use Only

Bradykinin-12-lipoxygenase-VR1 signaling pathway for inflammatory hyperalgesia: J. Shin, et al.; PNAS 99, 10150 (2002), Abstract
Direct activation of capsaicin receptors by products of lipoxygenases: endogenous capsaicin-like substances: S.W. Hwang, et al.; PNAS 97, 6155 (2000), Abstract
12-hydroperoxyeicosatetraenoic acid inhibits main platelet functions by activation of soluble guanylate cyclase: B. Brune & V. Ullrich; Mol. Pharmacol. 39, 671 (1991), Abstract
Inhibition of Ca2+/calmodulin-dependent protein kinase II by arachidonic acid and its metabolites: D. Piomelli, et al.; PNAS 86, 8550 (1989), Abstract
Stimulation of leukotriene biosynthesis in human blood leukocytes by platelet-derived 12-hydroperoxy-icosatetraenoic acid: J. Maclouf, et al.; PNAS 79, 6042 (1982), Abstract
Resolution of prostaglandin endoperoxide synthase and thromboxane synthase of human platelets: S. Hammarstrom & P. Falardeau; PNAS 74, 3691 (1977), Abstract

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12(S)-Hydroperoxyeicosa-5Z,8Z,10E,14Z-tetraenoic acid (HPETE)

BML-HP012

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

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