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1,2-Dioctanoyl-sn-glycerol (8:0)

BML-DG112

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PKC activator

Potent activator of protein kinase C (PKC). Membrane permeable but non-physiologic DAG. Induces a discrete but transient translocation of protein kinase C.

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Product Details

Alternative Name	DOG
Appearance	Clear colorless oil or waxy solid.
CAS	60514-48-9
Couple Target	PKC
Couple Type	Activator
Formula	C₁₉H₃₆O₅
Identity	Determined by 1H-NMR.
MW	344.5
Purity	≥96% (TLC)
Solubility	Soluble in DMSO or 100% ethanol.
Technical Info / Product Notes	Avoid acidic or basic conditions.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	At room temperature DOG is an oil. Due to its instability, keep it cool and dry.
Long Term Storage	-80°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Chitosan Mediates Germling Adhesion in Magnaporthe oryzae and Is Required for Surface Sensing and Germling Morphogenesis: I.A. Geoghegan & S.J. Gurr; PLoS Pathog. 12, e1005703 (2016), Application(s): Germinations in the presence of chemical inducers of appressorium development, Abstract — Full Text
Uremic Toxins Induce ET-1 Release by Human Proximal Tubule Cells, which Regulates Organic Cation Uptake Time-Dependently: C.M. Schophuizen, et al.; Cells 4, 234 (2015), Application(s): Cell Culture, Abstract — Full Text
1,2-Dioctanoyl-glycerol induces a discrete but transient translocation of protein kinase C as well as the inhibition of MCF-7 cell proliferation: M. Issandou & J.M. Darbon; BBRC 151, 458 (1988), Abstract
Further studies on the specificity of diacylglycerol for protein kinase C activation: M. Go, et al.; BBRC 144, 598 (1987), Abstract
Structural requirements of diacylglycerols for binding and activating phospholipid-dependent, Ca++-sensitive protein kinase: D.E. Kerr, et al.; BBRC 148, 776 (1987), Abstract
Diacylglycerols release LH: structure-activity relations reveal a role for protein kinase C: P.M. Conn, et al.; BBRC 126, 532 (1985), Abstract
Diacylglycerols mimic phorbol diester induction of leukemic cell differentiation: J.G. Ebeling, et al.; PNAS 82, 815 (1985), Abstract
Exogenous sn-1,2-diacylglycerols containing saturated fatty acids function as bioregulators of protein kinase C in human platelets: E.G. Lapetina, et al.; J. Biol. Chem. 260, 1358 (1985), Abstract — Full Text
sn-1,2-Dioctanoylglycerol. A cell-permeable diacylglycerol that mimics phorbol diester action on the epidermal growth factor receptor and mitogenesis: R.J. Davis, et al.; J. Biol. Chem. 260, 1562 (1985), Abstract — Full Text
Activation of protein kinase C by Triton X-100 mixed micelles containing diacylglycerol and phosphatidylserine: Y.A. Hannun, et al.; J. Biol. Chem. 260, 10039 (1985), Abstract — Full Text

Last modified: May 29, 2024

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1,2-Dioctanoyl-sn-glycerol (8:0)

BML-DG112

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