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12-Deoxyphorbol 13-acetate

BML-PE187

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PKC activator

A non-tumor promoting phorbol ester, which acts as a PKC partial agonist. Protects T-lymphoblastoid cells from the killing effects of HIV-1. Upregulates latent HIV-1 provirus expression and inhibits HIV infection and viral spread at the entry/fusion step of viral life cycle. Does not induce tumor formation.

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Product Details

Alternative Name	Prostratin
Appearance	White to off white crystalline powder.
CAS	60857-08-1
Couple Target	PKC
Couple Type	Activator
Formula	C₂₂H₃₀O₆
MW	390.5
Purity	≥99% (HPLC, TLC)
Solubility	Soluble in 100% ethanol (25mg/ml) or DMSO (25mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Effects of prostratin on Cyclin T1/P-TEFb function and the gene expression profile in primary resting CD4+ T cells: T.L. Sung & A.P. Rice; Retrovirology 3, 66 (2006), Abstract
Prostratin as a new therapeutic agent targeting HIV viral reservoirs: M. Hezareh; Drug News Perspect. 18, 496 (2005), Abstract
Prostratin antagonizes HIV latency by activating NF-kappaB: S.A. Williams, et al.; J. Biol. Chem. 279, 42008 (2004), Abstract
Nonpromoting 12-deoxyphorbol 13-esters inhibit phorbol 12-myristate 13-acetate induced tumor promotion in CD-1 mouse skin: Z. Szallasi, et al.; Cancer Res. 53, 2507 (1993), Abstract
A nonpromoting phorbol from the samoan medicinal plant Homalanthus nutans inhibits cell killing by HIV-1: K.R. Gustafson, et al.; J. Med. Chem. 35, 1978 (1992), Abstract
New tigliane and daphnane derivatives from Pimelea prostrata and Pimelea simplex: S. Zayed, et al.; Experientia 33, 1554 (1977), Abstract
The structure of prostratin: a toxic tetracyclic diterpene ester from Pimelea Prostrata: A.R. Cashmore & R.N. Seelye; Tetrahedron Lett. 17, 1737 (1976)

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12-Deoxyphorbol 13-acetate

BML-PE187

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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