Home Shop 1-Oleoyl-2-acetyl-sn-glycerol

1-Oleoyl-2-acetyl-sn-glycerol

BML-DG125

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PKC activator

In vitro potent activator of protein kinase C (PKC). Stimulator of secretion and aggregation in blood platelets. Stimulates formation of actin nucleation sites. Stimulation of pp60c-src phosphorylation in EBV transformed B-cells, 470μM.

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Product Details

Alternative Name	OAG
Appearance	Colorless oil or waxy solid.
CAS	86390-77-4
Couple Target	PKC
Couple Type	Activator
Formula	C₂₃H₄₂O₅
MW	398.6
Purity	≥95% (TLC)
Solubility	Soluble in DMSO or ethanol.
Source	Synthetic.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

New patterns of diacylglycerol metabolism in intact cells: J. Florin-Christensen; Biochem. J. 289, 783 (1993), Abstract
Diacylglycerol-stimulated formation of actin nucleation sites at plasma membranes: A. Shariff & E.J. Luna; Science 256, 245 (1992), Abstract
Opposite effects of angiotensin II and the protein kinase C activator OAG on cardiac Na+ channels: I. Benz, et al.; J. Membr. Biol. 130, 183 (1992), Abstract
Ca2+ and partly GTP gamma S-dependent particulate phospholipase C hydrolyzing phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate is inhibited by diacyl(acyl-acetyl) glycerols: E.W. Haeffner & U. Wittmann; J. Lipid Mediat. 5, 237 (1992), Abstract
Structural requirements of diacylglycerols for binding and activating phospholipid-dependent, Ca++-sensitive protein kinase: D.E. Kerr, et al.; Biochem. Biophys. Res. Commun. 148, 776 (1987), Abstract
Phorbol ester and diacylglycerol induce protein phosphorylation at tyrosine: T. Gilmore & G.S. Martin; Nature 306, 487 (1983), Abstract
Ca2+ and protein kinase C: Two synergistic cellular signals: B. Michell; Trends Biochem. Sci. 8, 263 (1983), (Review)
A possible role of protein kinase C in signal-induced lysosomal enzyme release: N. Kajikawa, et al.; BBRC 116, 743 (1983), Abstract
Diacylglycerol and phorbol ester stimulate secretion without raising cytoplasmic free calcium in human platelets: T.J. Rink, et al.; Nature 305, 317 (1983), Abstract
Synergistic functions of protein phosphorylation and calcium mobilization in platelet activation: K. Kaibuchi, et al.; J. Biol. Chem. 258, 6701 (1983), Abstract — Full Text

Last modified: May 29, 2024

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1-Oleoyl-2-acetyl-sn-glycerol

BML-DG125

Product Details

Handling & Storage

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