Home Shop 1-O-Hexadecyl-2-O-acetyl-sn-glycerol

1-O-Hexadecyl-2-O-acetyl-sn-glycerol

BML-EI150

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PKC inhibitor

Inhibits protein kinase C activation by diacylglycerols. Stimulates HL-60 cell differentiation. Biosynthetic precursor of PAF via remodeling and retroconversion/de novo routes. Induces delayed aggregation of rabbit platelets. Mitogenic for smooth muscle cells.

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Product Details

Appearance	Waxy solid.
CAS	77133-35-8
Couple Target	PKC
Couple Type	Inhibitor
Formula	C₂₁H₄₂O₄
MW	358.6
Purity	≥95% (TLC)
Solubility	Soluble in 100% ethanol or acetone.
Technical Info / Product Notes	Avoid acidic or basic conditions. Note: Product is not sterile

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored at -20°C. Stock solutions are stable for up to 6 months at -20°C.
Handling	Hygroscopic. Protect from moisture.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Is there an interplay between the SARS-CoV-2 spike protein and Platelet-Activating factor?: S. Antonopoulou, et al.; Biofactors 48, 1271 (2022), Abstract
Platelet Activating Factor (PAF) biosynthesis is inhibited by phenolic compounds in U-937 cells under inflammatory conditions: I.C. Vlachogianni, et al.; Prostaglandins Other Lipid Mediat. 121, 176 (2015), Abstract
Regulation of the synthesis of platelet-activating factor and its inactive storage precursor (1-alkyl-2-acyl-sn-glycero-3-phosphocholine) from 1-alkyl-2-acetyl-sn-glycerol by rabbit platelets: T.C. Lee, et al.; J. Biol. Chem. 265, 9181 (1990), Abstract
1-O-alkyl-2-acetyl-sn-glycerol: a platelet-activating factor metabolite with biological activity in vascular smooth muscle cells: L.L. Stoll, et al.; Cell Regul. 1, 13 (1989), Abstract
Alkyl-linked diglycerides inhibit protein kinase C activation by diacylglycerols: L.W. Daniel, et al.; BBRC 151, 291 (1988), Abstract
A new class of antihypertensive neutral lipid: 1-alkyl-2-acetyl-sn- glycerols, a precursor of platelet activating factor: M.L. Blank, et al.; BBRC 118, 344 (1984), Abstract
1-0-Hexadecyl-2-acetyl-sn-glycerol stimulates differentiation of HL-60 human promyelocytic leukemia cells to macrophage-like cells: M.J.C. McNamara, et al.; BBRC 122, 824 (1984), Abstract
Metabolism of 1-O-alkyl-2-acetyl-sn-glycerol by washed rabbit platelets: formation of platelet activating factor: K. Satouchi, et al.; Arch. Biochem. Biophys. 234, 318 (1984), Abstract
Conversion of 1-alkyl-2-acetyl-sn-glycerols to platelet activating factor and related phospholipids by rabbit platelets: M.L. Blank, et al.; BBRC 124, 156 (1984), Abstract

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1-O-Hexadecyl-2-O-acetyl-sn-glycerol

BML-EI150

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

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