1-EBIO

• GMP format available

1-EBIO is a potent activator of calcium-activated potassium (KCa) channels, specifically targeting small and intermediate conductance KCa channels. It has an EC50 of 490 µM in T84 human carcinoma cells.

Key features and applications include:

• High Selectivity: Activates KCa channels with high specificity.
• Potency: Demonstrates strong activation with an EC50 of 490 µM.
• Stimulate Cl^– Secretion: Induces a large and sustained trans-epithelial Cl- secretory response across T84 monolayers.
• Promote Hyperpolarization: Causes hyperpolarization in aortic valve endothelial cells to the same magnitude as acetylcholine.
• Enhance Stem Cell Differentiation: Promotes differentiation of embryonic stem cells into cardiomyocytes.

Relevant disease states include:

• Cystic Fibrosis: Enhances residual function of mutant CFTR in rectal biopsies from cystic fibrosis patients.
• Cardiovascular Diseases: Induces hyperpolarization and nitric oxide formation in endothelial cells, which can be beneficial in cardiovascular research.
• Neuroprotection: Increases small conductance Ca²⁺-activated potassium channel activity, which has neuroprotective effects in ischemia-induced neuronal cell death.