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1-Azakenpaullone

ALX-270-430

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GSK-3β inhibitor

Analog of kenpaullone (Prod. No. BML-EI310) acting as a potent and ATP-competitive inhibitor of GSK-3β (IC₅₀=18nM). Displays ~100-200 fold greater selectivity on GSK-3β than over CDK1/cyclin B and CDK5/p25 (IC₅₀=2.0µM and 4.2µM, respectively).

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Product Details

Alternative Name	9-Bromo-7,12-dihydropyrido[3′,2′:2,3]azepino[4,5-b]indol-6(5H)-one, 1-AKP
Appearance	Off-white to brown powder.
CAS	676596-65-9
Couple Target	GSK
Couple Type	Inhibitor
Formula	C₁₅H₁₀BrN₃O
MW	328.2
Purity	≥95% (HPLC, TLC)
Solubility	Soluble in DMSO; insoluble in water.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stock solutions are stable for up to 6 months when stored at -20°C.
Handling	Protect from moisture. Protect from light.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

GSK3β-dependent phosphorylation alters DNA binding, transactivity and half-life of the transcription factor USF2: Horbach, T., Chi, T. F., et al.; PLoS One 9, e107914 (2014), Abstract
A chemical biology approach reveals period shortening of the mammalian circadian clock by specific inhibition of GSK-3beta: T. Hirota, et al.; PNAS USA 105, 20746 (2008), Abstract — Full Text
Novel CDK inhibition profiles of structurally varied 1-aza-9-oxafluorenes: B. Voigt, et al.; Bioorg. Med. Chem. Lett. 15, 823 (2005), Abstract
1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3 beta: C. Kunick, et al.; Bioorg. Med. Chem. Lett. 14, 413 (2004), Abstract

Related Products

Kenpaullone

BML-EI310

Inhibitor of CDK and GSK

10 citations

Alternative Name	9-Bromo-7,12-dihydroindolo-[3,2-d][1]benzazepin-6(5H)-one
CAS	142273-20-9
Couple Type	Inhibitor
Purity	≥98% (TLC)

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1-Azakenpaullone

ALX-270-430

Product Details

Handling & Storage

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