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1-Aminobenzotriazole

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Cytochrome P450 inhibitor

Suicide substrate for cytochrome P-450. Inhibits oxidative drug metabolism in vivo. Blocks ω-oxidation of arachidonic acid but not epoxidation.

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Appearance	White to gray to brown powder to crystal.
CAS	1614-12-6
Couple Target	Cytochrome P450
Couple Type	Inhibitor
Formula	C₆H₆N₄
MW	134.1
Purity	≥98% (GC)
Solubility	Soluble in water.

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

1-Aminobenzotriazole-induced destruction of hepatic and renal cytochromes P450 in male Sprague-Dawley rats: C. A. Mugford, et al.; Fundam. Appl. Toxicol. 19, 43 (1992), Abstract
In vivo inhibition of oxidative drug metabolism by, and acute toxicity of, 1-aminobenzotriazole (ABT). A tool for biochemical toxicology: B. A. Mico, et al.; Biochem. Toxicol. 37, 2515 (1988), Abstract
Inactivation of rabbit pulmonary cytochrome P-450 in microsomes and isolated perfused lungs by the suicide substrate 1-aminobenzotriazole: J. M. Mathews, et al.; J. Pharmacol. Exp. Ther. 235, 186 (1985), Abstract

Last modified: May 29, 2024

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