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γ-Amanitin

ALX-350-272

10 citations

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RNA polymerase II inhibitor

Biological activity like α-amanitin.

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Product Details

Alternative Name	EL-Amanitin
Appearance	White to off-white powder.
CAS	21150-23-2
Couple Target	RNA polymerase
Couple Type	Inhibitor
Formula	C₃₉H₅₄N₁₀O₁₃S
MI	14: 373
MW	903.0
Purity	≥90%
Solubility	Soluble in DMF, DMSO, and 100% methanol.
Source	Isolated from Amanita phalloides mushrooms.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Dilute with buffer immediately prior to use. Product is destroyed by concentrated acid or base.
Handling	Protect from light.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Erdosteine reduces cytotoxicity induced by alpha- and beta-amanitin, but not gamma-amanitin, in CA3 hepatocyte cultures: R. Bayram, et al.; Toxicon 213, 52 (2022), Abstract
An automated and highly sensitive chemiluminescence immunoassay for diagnosing mushroom poisoning: J. Zhu, et al.; Front. Chem. 9, 813219 (2021), Abstract — Full Text
First report of a neotropical Agaric (Lepiota spiculata, Agaricales, Basidiomycota) containing lethal α-amanitin at toxicologically relevant levels: C. Angelini, et al.; Front. Microbiol. 11, 1833 (2020), Abstract — Full Text
Highly sensitive determination of amanita toxins in biological samples using β-cyclodextrin collaborated molecularly imprinted polymers coupled with ultra-high performance liquid chromatography tandem mass spectrometry: L. Tan, et al.; J. Chromatogr. A 1630, 461514 (2020), Abstract
Lateral flow immunoassay (LFIA) for the detection of lethal amatoxins from mushrooms: C.S. Beyer, et al.; PLoS One 15, E0231781 (2020), Abstract — Full Text
Rapid, sensitive, and accurate point-of-care detection of lethal amatoxins in urine: C.S. Beyer, et al.; Toxins 12, 123 (2020), Abstract — Full Text
Toxin components and toxicological importance of Galerina marginata from Turkey: I. Akata, et al.; Toxicon 187, 29 (2020), Abstract
A rapid extraction method combined with a monoclonal antibody-based immunoassay for the detection of amatoxins: C.S. Beyer, et al.; Toxins 11, 724 (2019), Abstract — Full Text
Two new species of Amanita sect. Phalloideae from Africa, one of which is devoid of amatoxins and phallotoxins: A. Fraiture, et al.; MycoKeys 53, 93 (2019), Abstract — Full Text
A new conjugation method used for the development of an immunoassay for the detection of amanitin, a deadly mushroom toxin: C.S. Beyer, et al.; Toxins 10, 265 (2018), Abstract — Full Text

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γ-Amanitin

ALX-350-272

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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