Home Shop β-Catenin (NT/exon 2) monoclonal antibody (7D11)

β-Catenin (NT/exon 2) monoclonal antibody (7D11)

ALX-804-060

15 citations

Datasheet
Manual
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CofA

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Product Details

Application	ELISA, IHC, IP, WB
Clone	7D11
Formulation	Lyophilized from 1ml of 2x PBS containing 0.09% sodium azide, PEG, and sucrose.
Host	Mouse
Immunogen	Recombinant human β-catenin.
Isotype	IgG2a
Positive Control	Included. (Prod. No. ALX-840-027)
Purity Detail	Thiophilic adsorption and size exclusion chromatography purified.
Recommendation Dilutions/Conditions	Western Blot (0.5µg/ml for HRPO/ECL detection)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application.
Reconstitution	Reconstitute with 1ml water (15 minutes at room temperature).
Species Reactivity	Dog, Human, Mouse
Specificity	Recognizes the N-terminus (exon 2) of human, mouse, rat (weak) and dog β-catenin.
UniProt ID	P35222
Worry-free Guarantee	This antibody is covered by our Worry-Free Guarantee.

Handling & Storage

Use/Stability	Stable at -80°C up to 1 year, at 4°C up to 3 months.
Handling	Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and freeze in liquid nitrogen.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

GATA3 mediates nonclassical β-catenin signaling in skeletal cell fate determination and ectopic chondrogenesis: T. Maruyama, et al.; Sci. Adv. 8, eadd6172 (2022), Application(s): IHC / Reactant(s) Mouse, Abstract
Distinct adhesion-independent functions of β-catenin control stage-specific sensory neurogenesis and proliferation.: Basler, K., Sommer, L., et al.; BMC Biol. 13, 24 (2015), Application(s): IHC / Reactant(s): Mouse, Abstract
STAT3 paradoxically stimulates β‐catenin expression but inhibits β‐catenin function: S. Ibrahem, et al.; Int. J. Exp. Pathol. 95, 392 (2014), Application(s): WB, Abstract
Relation between expression pattern of wild-type p53 and multidrug resistance proteins in human nephroblastomas: I. Hodorova, et al.; Acta Histochem. 115, 273 (2013), Application(s): Immunohistochemistry of human tissue, Abstract
Phospho-beta-catenin accumulation in Alzheimer’s disease and in aggresomes attributable to proteasome dysfunction: M. Ghanevati & C.A. Miller; J. Mol. Neurosci. 25, 79 (2005), Abstract
The human F box protein beta-Trcp associates with the Cul1/Skp1 complex and regulates the stability of beta-catenin: E. Latres, et al.; Oncogene 18, 849 (1999), Abstract
Abnormal immunoreactivity of the E-cadherin-catenin complex in gastric carcinoma: relationship with patient survival: A. Jawhari, et al.; Gastroenterology 112, 46 (1997), Abstract
Beta-catenin mutations in cell lines established from human colorectal cancers: M. lyas, et al.; Proc. Natl. Acad. Sci. USA 94, 10330 (1997), Abstract
beta-catenin is a target for the ubiquitin-proteasome pathway: H. Aberle, et al.; EMBO J. 16, 3797 (1997), Abstract
XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos: M. Molenaar, et al.; Cell 86, 391 (1996), Abstract

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Datasheet

Specific Protocol

Recommended blocking buffer CPPT: 10mM TRIS-HCl, pH 7.4, 0.5% (w/v) casein, 1% (w/v) PEG 4,000, 1% (w/v) polyvinylpyrrolidone, 0.1% (v/v) Tween 20, 150mM sodium chloride.

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