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α-Latrotoxin

ALX-630-027

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Neurotoxin

Causes massive neurotransmitter release from a wide variety of central and peripheral synaptic junctions of vertebrates using Ca²⁺-dependent and Ca²⁺-independent pathways. A useful pharmacological tool in the studies of synaptic vesicles exocytosis of different neutrotransmitters.

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Product Details

CAS	65988-34-3
Formulation	Lyophilized.
MW	~130kDa.
Purity	≥97%
Purity Detail	Migrates as one distinct band when run on a 5-25% gradient polyacrylamide gel according to the method of Laemmli (Nature 227, 680 (1970)).
Quality Control	Bioassay: Test of the ability to stimulate neurotransmitter release in both Ca²⁺-free and Ca²⁺-containing media according to Valtorta. Effective concentration: 100pM-1nM.
Quantity	Determined by Lowry and Pierce method.
RTECS	OE9020000
Reconstitution	Reconstitute in 0.5ml of distilled cold water. Stir very gently. Do not shake or vortex. Add 0.5 ml glycerol. Stock solution received contains 50% glycerol and 300nM α-latrotoxin.
Source	Isolated from Latrodectus tredecimguttatus.
Technical Info / Product Notes	Attention: For best results, only proceed according to the given instructions. Dissolution and/or storage of this toxin contrary to these instructions may affect the stability and biological activity of this compound.
UniProt ID	P23631

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stock solution is stable for 1 week when stored at +4°C or for at least one year at -20°C.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Heterogenous impairment of α cell function in type 2 diabetes is linked to cell maturation state: Dai, X. Q., Camunas-Soler, J., et al.; Cell Metab. 34, 256 (2022), Abstract
Cell-Based Reporter Release Assay to Determine the Activity of Calcium-Dependent Neurotoxins and Neuroactive Pharmaceuticals: A.P. Neuschäfer-Rube, et al.; Toxins (Basel) 13, 247 (2021), Abstract — Full Text
Activity-dependent regulation of mitochondrial motility in developing cortical dendrites: C.A. Silva, et al.; Elife 7554, e62901 (2021), Abstract
Neurexin-1α regulates neurite growth of rat hippocampal neurons: A. Wang, et al.; Int. J. Physiol. Pathophysiol. Pharmacol. 11, 115 (2019), Application(s): ICC-IF, Abstract — Full Text
Alpha-latrotoxin induces exocytosis by inhibition of voltage-dependent K+ channels and by stimulation of L-type Ca2+ channels via latrophilin in beta-cells: S. Lajus, et al.; J. Biol. Chem. 281, 5522 (2006), Abstract
alpha-Latrotoxin and its receptors: neurexins and CIRL/latrophilins: T.C. Sudhof; Annu. Rev. Neurosci. 24, 933 (2001), (Review), Abstract
Mechanisms of alpha-latrotoxin action: A. W. Henkel & S. Sankaranarayanan; Cell Tissue Res. 296, 229 (1999), (Review), Abstract
Alpha-latrotoxin stimulates glutamate release from cortical astrocytes in cell culture: V. Parpura, et al.; FEBS Lett. 360, 266 (1995), Abstract
GTP cleavage by the small GTP-binding protein Rab3A is associated with exocytosis of synaptic vesicles induced by alpha-latrotoxin: B. Stahl, et al.; J. Biol. Chem. 269, 24770 (1994), Abstract — Full Text
The effect of alpha-latrotoxin on a synaptic connection between identified neurons in the brain of the mollusc Helix pomatia L: O.N. Osipenko, et al.; Toxicon 31, 1123 (1993), Abstract

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α-Latrotoxin

ALX-630-027

Product Details

Handling & Storage

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