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Epibatidine is an analgesic alkaloid isolated from the skin of the poison frog Epipedobates tricolor. It is the most potent nicotinic acetylcholine receptor agonist known. The natural (+) enantiomer is only 2-fold more potent than the (-) enantiomer with respect to analgesic activity in mice. Both enantiomers bind with high affinity (Ki=0.045 and 0.058 nM respectively) to rat brain membrane nicotinic receptors.
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Last modified: May 29, 2024