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(±)-Huperzine A

ALX-550-064

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Acetylcholine esterase inhibitor

Racemic modification of (-)-Huperzine A (Prod. No. ALX-550-065) with acetylcholinesterase inhibitor activity. Has a weaker biological activity than (-)Huperzine A. Neurotoxic.

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Product Details

Alternative Name	(±)-Selagine
Appearance	Off-white solid.
CAS	120786-18-7
Couple Target	Acetylcholine esterase
Couple Type	Inhibitor
Formula	C₁₅H₁₈N₂O
MI	14: 4755
MW	242.3
Purity	≥95%
Solubility	Soluble in dilute aqueous acids or chloroform.
Source	Synthetic.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Influence of the Melissa officinalis Leaf Extract on Long-Term Memory in Scopolamine Animal Model with Assessment of Mechanism of Action: M. Ozarowski, et al.; Evid. Based Complement. Alternat. Med. 2016, 9729818 (2016), Abstract
Progress in studies of huperzine A, a natural cholinesterase inhibitor from Chinese herbal medicine: R. Wang, et al.; Acta Pharmacol. Sin. 27, 1 (2006), Abstract
Huperzine A, a potential therapeutic agent for treatment of Alzheimer’s disease: D.L. Bai, et al.; Curr. Med. Chem. 7, 355 (2000), (Review), Abstract
Huperzine A ameliorates the spatial working memory impairments induced by AF64A: Q.X. Zhi, et al.; NeuroReport 6, 2221 (1995), Abstract
An Improved Synthetic Route to Huperzine A; New Analogues and Their Inhibition of Acetylcholinesterase: A.P. Kozikowski, et al.; J. C. S. Chem. Commun. , 860 (1993)
Mechanism of inhibition of cholinesterases by huperzine A: Y. Ashani, et al.; BBRC 184, 719 (1992), Abstract
Potencies and stereoselectivities of enantiomers of huperzine A for inhibition of rat cortical acetylcholinesterase: M. McKinney, et al.; Eur. J. Pharmacol. 203, 303 (1991), Abstract
Synthesis and Biological Evaluation of (±)-Z-Huperzine A: A.P. Kozikowski, et al.; Tetrahedron Lett. 31, 6159 (1990)
Effect of huperzine A, a new cholinesterase inhibitor, on the central cholinergic system of the rat: X.C. Tang, et al.; J. Neurosci. Res. 24, 276 (1989), Abstract
A practical synthesis of the Chinese nootropic” agent huperzine A: a possible lead in the treatment of Alzheimer’s disease”””: Y. Xia & A.P. Kozikowski; JACS 111, 4116 (1989)

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(±)-Huperzine A

ALX-550-064

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