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(±)-Taxifolin

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Antioxidant flavonoid

Antioxidant flavonoid.

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Alternative Name	(±)-Dihydroquercetin, (±)-3,3′,4′,5,7-Pentahydroxyflavanone, Taxifoliol, Distylin, Catechin hydrate
Appearance	White to slightly brown powder.
CAS	17654-26-1
Formula	C₁₅H₁₂O₇
Identity	Determined by NMR.
MW	304.3
Purity	≥95% (HPLC)
RTECS	LK6920000
Solubility	Soluble in 100% ethanol.

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Development of silymarin topical formulation: In vitro and ex vivo dermal kinetics of silymarin: V.K. Shankar, et al.; Int. J. Pharm. 630, 122431 (2023), Abstract
Inhibitory activity of diacylglycerol acyltransferase (DGAT) and microsomal triglyceride transfer protein (MTP) by the flavonoid, taxifolin, in HepG2 cells: potential role in the regulation of apolipoprotein B secretionInhibitory activity of diacylglycero: A. Casaschi, et al.; Atherosclerosis 176, 247 (2004), Abstract
Modulation of hepatic lipoprotein synthesis and secretion by taxifolin, a plant flavonoid: A. Theriault, et al.; J. Lipid Res. 41, 1969 (2000), Abstract
Structure-antioxidant activity relationships of flavonoids and phenolic acids: C.A. Rice-Evans, et al.; Free Radic. Biol. Med. 20, 933 (1996), (Review), Abstract
Interaction of flavonoids with ascorbate and determination of their univalent redox potentials: a pulse radiolysis study: W. Bors, et al.; Free Radic. Biol. Med. 19, 45 (1995), Abstract
Suppression of hydroperoxide-induced cytotoxicity by polyphenols: T. Nakayama; Cancer Res. 54, 1991s (1994), Abstract
Suppression of active oxygen-induced cytotoxicity by flavonoids: T. Nakayama, et al.; Biochem. Pharmacol. 45, 265 (1993), Abstract

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