AMPIVIEW® RNA probes
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The FLUOR DE LYS® SIRT1 substrate, the recommended substrate, is provided in the kit. The FLUOR DE LYS® SIRT1 substrate is a peptide comprising amino acid 379-382 of human p53 (Arg-His-Lys-Lys (Ac)). The fluorescence signal is generated in proportion to the amount of deacetylation of the lysine corresponding to Lys-382, a known in vivo target of SIRT1 activity. The FLUOR DE LYS® SIRT1 is the substrate deacetylated most efficiently by SIRT1 from among a panel of substrates patterned on p53, histone H3, and histone H4 acetylation sites. Please see Figure 2 of the kit insert.