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Both our PROTEOSTAT® Aggresome detection kit (ENZ51035) and PROTEOSTAT® Protein Aggregation Assay (ENZ-51023) rely on the properties of our PROTEOSTAT® dye. This is a novel red fluorescent molecular rotor dye which intercalates in the cross-beta spline of stacked beta-sheets characteristic of the quarternary structure of protein aggregates and becomes bright fluorescent upon intercalation. The PROTEOSTAT® dye thus specifically stains aggregated proteins.It does not detect naive dimer-/ oligomer-/multimerisation of proteins.
The difference between both kits is that the formulation of the dye and the kit components have been optimized to either detect protein aggregates in a liquid solution in the PROTEOSTAT® Protein Aggregation Assay (ENZ-51023), or in a cellular context in the PROTEOSTAT® Aggresome detection kit (ENZ51035). Our PROTEOSTAT® Protein Aggregation Assay is best suited when studying aggregation properties of a protein of interest in solution or detecting the presence of aggregates, for example as part of a quality control process in the manufacturing of proteins.
Our PROTEOSTAT® Aggresome detection kit on the other hand was optimized to visualize and quantify protein aggregates within cells, as they for example form in inclusion bodies, aggresomes, or extracellular fibrilar aggregates.