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ProteoStat® dyes belongs to the class of molecular rotor dyes. They are non-fluorescent in solution due to free rotation around a central carbon-carbon single bond separating different aromatic portions of the probes. When the molecular rotor dye encounters protein aggregates, it locks into the fibrils that hold beta sheets together and becomes highly fluorescent. This is analogous to the fluorescence enhancement upon intercalation of ethidium bromide between the bases of nucleic acid.
The ProteoStat® Thermal Shift Stability Assay kit, ENZ-51027, provides an assay format that allows direct monitoring of protein aggregation arising from thermally-induced protein denaturation without detecting the hydrophobic regions exposed through protein unfolding. The kit is used for determining the effect of buffers and other added excipients on overall stability of a protein, and for determining the temperature at which a protein becomes aggregated under a given condition.
ProteoStat® Protein Aggregation Assay kit, ENZ-51023, provides a simple, homogenous assay format for detecting peptide and protein aggregation formation in solution. It is useful for defining optimal storage formulations for proteins, for screening promoters or inhibitors of protein aggregation, and for measurement of molecular chaperone activity. Combined with a set of standards or samples of known concentration, this kit can be utilized for quantitative determination of protein aggregation.
ProteoStat® Aggresome Detection Kit, ENZ-51035, is optimized to detect denatured protein cargo within aggresomes and aggresome-like inclusion bodies in live cells. The ProteoStat® Aggresome Detection dye becomes brightly fluorescent upon binding to aggregated proteins within vesicles during ggresome formation and has been validated for flow cytometry and fluorescence microscopy.