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Common labels include biotin, digoxigenin, and fluorochromes. Biotin is detected with streptavidin- conjugated enzymes followed by an enzymatic colorimetric reaction. Digoxigenin is detected with antibodies. Much like secondary antibodies in immunostaining, these can be coupled to biotin or enzymes for colorimetric detection or fluorochromes for fluorescent detection. Finally, fluorochrome-conjugated nucleotides can be used to label the DNA directly for fluorescence ISH https://www.enzolifesciences.com/platforms/genomics/nucleotides/modified-nucleotides—nick-translation/.