My compound dissolved well into DMSO, but when I tried to dilute this DMSO stock solution with aqueous media precipitate formed. What should I do?

Date Published: July 18, 2023

It is common for compounds to precipitate when a stock solution in a solvent such as DMSO is diluted with aqueous media. Most of these precipitates will redissolve with a few minutes of vortexing or sonication, or brief warming in a 37°C water bath with sonication. While this type of precipitation will not harm the compound, it is important to take the time to be sure the precipitate has completely redissolved before using the solution.

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