HSP70B’ is a product of a separate gene, which is devoid of introns similarly to HSP70. The HSP70B’ has 77% sequence identity to HSP70 gene and 70% identity to HSC70 cDNA with highest sequence divergence at the 3′-end. Promoter studies have shown HSP70B’ to be a unique member of the HSP70 family. Unlike HSP70 which shows basal levels of expression and is induced by heat and various stressors, HSP70B’ is strictly heat-inducible and shows no basal level (Flaherty KM et al., 1994).

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