Restriction digestion or fragmentation of the isolated genomic DNA is not required prior to labeling with our CYTAG® CGH (ENZ-42671) and CYTAG® Super CGH (ENZ-GEN120) Labeling Kits. Our CYTAG® TotalCGH Labeling Kit (ENZ-42674) requires DNA fragmentation by enzymatic digestion with the included restricion enzymes when single nucleotide polymorphism (SNP) analysis is being performed.