HTS/HCS

Unleashing the Power of Millions

Rapidly screen large chemical libraries to identify potential drug candidates for further development

High-throughput screening (HTS) and high-content screening (HCS) are powerful techniques used in drug discovery to rapidly evaluate large libraries of compounds for their biological activity or effect on cellular processes. HTS involves the automated screening of thousands to millions of compounds against biological targets, allowing for the identification of potential drug candidates. HCS, on the other hand, combines HTS with imaging technology to analyze multiple cellular parameters simultaneously, providing detailed information about cellular morphology, function, and signaling pathways. Together, HTS and HCS enable researchers to efficiently identify promising drug candidates and gain insights into their mechanisms of action, accelerating the drug discovery process.

Curated Libraries Streamline Your Screening Process

Enzo Life Sciences has a long and successful track record in identifying, synthesizing, and commercializing valuable known bioactives for use as research tools. Our long-standing, flagship SCREEN-WELL® Compound Library product family offers an easy, ready-to-use method for compound screening. Our unique offering of focused compound libraries includes FDA-approved drugs, natural products, receptor de-orphaning, chemical genomics, and pathway targeting.

SCREEN-WELL® Compound Libraries

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A unique collection of small molecules including inhibitors, activators and/or inducers
Complete documentation set that highlights activity descriptions, plate positions, physical information and a structural database (SD) file
The ability to re-supply individual bulk compounds, custom libraries, or hard to source compound

Monitor Activity Of Therapeutic Compounds

High-throughput Screening for Multidrug Resistance

The Only Assay for Functional Detection of All Three Clinically Relevant ABC Transporter Proteins

Quantitative measurements of multidrug resistance activity in live cells
Simple and reproducible mix-and-read protocol optimized for flow cytometry
Two dye formats allows multiplexing

Profiling of ABC transporter activity by known inhibitors was assessed in CHO K1 cells using EFLUXX-ID® Green and eFluxx-ID® Gold dyes.

Small Molecules

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Our chemistry and compound range includes over 3,000 stand-alone small molecules with known activity including natural products, enzyme inhibitors, receptor ligands, drugs, lipids, and fatty acids.

Our staff of organic chemists are experienced in diverse synthetic methods and techniques. We welcome requests for custom services including development of new synthetic routes for novel molecules and rapid sourcing of compounds.

Through our supplier network, built over a 25 year history, we have the ability to rapidly and inexpensively source traditional, custom, and bulk compounds in the gram to kilogram scale. We complete our sourcing using stringent quality control standards with state-of-the-art methods.

Choose from Over 3,000 Compounds

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Natural Products
Enzyme inhibitors
Receptor Ligands
Drugs

Lipids
Fatty Acids
Antagonists
… and much more

Bulk / Custom Sourcing of Compounds

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GMP Services

Infinite Possibilities for Customization

Natural Products & Antibiotics

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Natural products are chemical compounds or substances produced by a living organism that usually have a pharmacological or biological activity for use in drug discovery. Modern clinically useful natural product-derived drugs include aspirin, quinine, Paclitaxel (Taxol®) and Artemisinin. Microorganisms produce a large variety of antimicrobial agents, and marine organisms have proven a rich source of potent chemicals with inflammatory, antiviral, and anticancer activity. Venoms and toxins often specifically interact with a macromolecular target in the body. As a result, they are important tools in studying receptors, ion channels, and enzymes.

Enzo provides a comprehensive collection of over 800 natural products and rare antibiotics for the drug discovery, diagnostics, and life sciences research market.

Cell Based Assays

Visualize cellular responses under physiological and pathological conditions

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Enzo solutions for cellular analysis enable investigation of basic cell biology, its relation to disease pathology, and the development of novel small molecule, biotherapeutic, and cell based therapies. Built upon our diverse scientific expertise and technology platforms, we support cellular analysis on the genomic, protein, small molecule and whole cell level.