Mitochondrial Toxicity

Visualize Toxic Events In Vitro

Mitochondria are remarkable organelles that generate ATP to meet the energy needs of cells. They also take in calcium, an important cell signaling molecule, monitor and maintain conditions in the cell and help regulate apoptosis, cellular metabolism, and proliferation. Mitochondrial toxicity can damage many organs and tissues such as the liver, heart, and muscle. Mitotoxicity has become a significant concern for pharmaceutical industries. It can induce severe and sometimes fatal liver injury that can disrupt clinical trials or lead to post-market drug withdrawal. Evaluations of mitochondrial toxicity usually measure ATP content or mitochondrial membrane potential.