Hepatotoxicity

Visualize Toxic Events In Vitro

Cytotoxicity is measured primarily as damage to living cells and initiation of cell death and presents in similar ways across cell types. Hepatocytes are important in predictive toxicity studies due to the metabolic drug activities that make them more susceptible to drug compounds. Cell death can be determined by measuring the leakage of cell components, presenting information about membrane integrity and dying cells’ mechanism. Standard measures of cell death include lactate dehydrogenase (LDH), DNA binding dyes, or measuring dead cell-specific protease activity. Cell viability can also be used in tandem with cell death markers, most commonly tested by measuring ATP (a measure of living and competent cells).