Genotoxicity

Visualize Toxic Events In Vitro

Evaluation of the genotoxicity effects of various materials for use as drug components is a required aspect of product development. Identifying genotoxic drug compounds during early preclinical studies allows for further lead refinement and lower drug attrition. Genotoxins can be carcinogens, mutagen or teratogens. The genotoxic substances induce damage to the genetic material in the cells through interactions with the DNA sequence and structure. The alteration can have direct or indirect effects on the DNA.
To evaluate genotoxicity, different in vitro and in vivo methodologies are used, including Ames test, Comet assay, micronucleus test, and others. Combining multiple assays is necessary to build a complete picture of a drug candidate’s genotoxic potential.