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Antibody Drug Conjugates
Empowering Targeted Precision for Enhanced Therapeutic Impact
Cutting-Edge Solutions for Advancing Targeted Therapies
Antibody Drug Conjugates (ADCs) are a class of targeted biopharmaceuticals that combine the specificity of monoclonal antibodies with the potency of cytotoxic drugs. They are designed to selectively deliver cytotoxic payloads to specific cells, typically cancer cells, while sparing healthy cells. ADCs consist of three main components:
- Monoclonal Antibody: The monoclonal antibody is engineered to recognize and bind to specific antigens present on the surface of cancer cells. This antibody acts as a homing device, guiding the ADC to its target.
- Linker: The linker serves as a bridge between the antibody and the cytotoxic drug. It is designed to be stable during circulation in the bloodstream but capable of releasing the cytotoxic drug once the ADC reaches its target cell.
- Cytotoxic Payload: The cytotoxic drug, often a potent chemotherapy agent, is attached to the ADC via the linker. Once the ADC is internalized by the target cell, the cytotoxic payload is released, leading to cell death.
By selectively delivering the cytotoxic payload to cancer cells, ADCs aim to enhance the therapeutic index by minimizing damage to healthy tissues and reducing side effects associated with traditional chemotherapy. ADCs offer the potential for targeted and personalized treatment options in the field of oncology, with the ability to improve efficacy and minimize systemic toxicity. Ongoing research and development in ADC technology hold promise for expanding the range of targeted therapies available to patients.
MEGACD40L® Protein (soluble)(human) (recombinant)
High-activity, high-purity CD40L construct for co-stimulatory activation of an immune response without enhancers.
- Superior purity eliminates experimental artifacts
- 100-fold lower endotoxin levels than comparable products
- Reliable results through consistent lot-to-lot performance
Achieve rapid expansion of primary B cells with MEGACD40L® recombinant protein. Using MEGACD40L® in association with other stimulants can improve expansion of primary B cells by 36 fold, based on the work by Hung KL, et alz
Enhance Immune Activation with MEGACD40L® Protein
Small Molecules and Peptides
Incorporating small molecules into bioprocessing workflows can enhance productivity at various stages of the production cycle. These molecules act as potent enhancers, catalysts, or modulators, driving improvements in yield, quality, and overall process performance.
Our chemistry and compound range includes over 3,000 stand-alone small molecules with known activity, including natural products, enzyme inhibitors, receptor ligands, drugs, lipids, and fatty acids. From metabolic engineering to downstream processing, these compounds offer unprecedented opportunities to enhance productivity, streamline workflows, and achieve greater efficiency in producing valuable biologics.
Protein A ELISA Kit
The Protein A ELISA kit is a sensitive and reproducible sandwich immunoassay to quantify Protein A residuals in monoclonal antibody preparations.
- Highly sensitive measurement, detecting as little as 9.01 pg/ml (<1 ppm) of Protein A residuals in purified humanized mAb preparations
- Universally used as it recognizes 4 commonly used constructs of Protein A
- High-throughput format with results in under 3 hours for up to 37 samples in duplicate
Recognition of all Commonly Used Protein A Constructs Ensures Accurate Results
Host Cell Protein ELISA Kits
The Host Cell Protein ELISA kits and reagents are ideal for impurity analysis. Quantitatively measure host cell protein contamination in E.coli, CHO, and HEK293T derived products.
- Sensitive measurement of host cell protein, detecting as little as 10 ng/ml
- High protein coverage greater than 70% thereby, reducing the risk of missing potential contaminants
- High-throughput format with results in as little as 3 hours
Monitor CHO HCP Residuals with Confidence
Antibiotics ELISA Kits
Simple, fast, and sensitive method to detect and quantify antibiotics in cell culture supernatants (bacterial and mammalian cells).
- Validated with bacterial and mammalian culture supernatants
- Highly specific and sensitive
- Cost effective and fast
Available for Neomycin, Gentamicin, and Streptomycin
Bovine Serum Albumin (BSA) ELISA Kit
BSA is a major component of fetal bovine serum (FBS), commonly used in mammalian cell culture media for recombinant biologics production.
Enzo’s BSA ELISA kit is simple, fast, sensitive and validated for use with multiple sample types.
To monitor BSA in various samples for optimizing purification process development and ensuring routine quality control of in-process streams and final products.
Human Serum Albumin (HSA) ELISA Kit
HSA nanoparticles have long been the center of attention in the pharmaceutical industry due to their ability to bind to various drug molecules, great stability during storage and in vivo usage, no toxicity and antigenicity, biodegradability, reproducibility, scale up of the production process and a better control over release properties.
Enzo’s HSA ELISA kit is sensitive, simple and is suitable for the detection of large number of samples.
To monitor HSA in various samples for optimizing purification process development and ensuring routine quality control of in-process streams and final products.
PROTEOSTAT® Protein Aggregation Assay
The PROTEOSTAT® Protein Aggregation Assay is a simple, sensitive, homogeneous fluorescent microplate assay. Utilizing a unique molecular rotor dye, this innovative method detects a wide spectrum of protein aggregates, ranging from visible to subvisible particles.
PROTEOSTAT® Thermal Shift Stability Assay
Based on an innovative molecular rotor dye, the PROTEOSTAT® Thermal Shift Stability Assay is a rapid, simple, and sensitive screening method allowing the end user to investigate the aggregation propensity of proteins by determing the temperature of aggregation.
Analytics and Characterization Tools
Robust analytical methods and characterization tools are crucial for assessing the quality, purity, and stability of antibody drug conjugates during development and manufacturing processes.
ELISA Assays
ELISA is an indispensable tool in ADC research and development. It provides critical data on antibody concentration, purity, conjugation efficiency, stability, pharmacokinetics, immunogenicity, and target antigen expression. This comprehensive analytical capability supports the development, optimization, and quality control of ADCs, ensuring they are safe, effective, and ready for clinical use.
Cytokines and Immune Markers ELISAs: Cytokines and immune markers are relevant in ADC research in the context of assessing immune responses and potential adverse effects. ELISA assays targeting specific cytokines or immune markers can provide insights into the immunogenicity and safety profile of the ADC.
- Interleukins (ILs): IL-2, IL-6, IL-10 ELISAs
- Tumor Necrosis Factor (TNF): TNF-alpha ELISA
- Inflammatory markers: C-reactive protein (CRP) ELISA
Monoclonal Antibodies (mAbs)
High-quality, validated mAbs that specifically target antigens expressed on cancer cells
Antibody Search
Key Antibodies
In the research and development of Antibody-Drug Conjugates (ADCs), several monoclonal antibodies (mAbs) are of particular importance due to their specific targeting capabilities and therapeutic potential. Here are some key monoclonal antibodies used in ADC research and development:
HER2, CD30, CD20, EGFR, VEGF, CD38, SLAMF7, CD33, CD22, TROP-2, Nectin-4, CD79b, CD25, B7-H3 (CD276), PSMA, Mesothelin, Glypican-3, ROR1, BCMA, PD-1, PDL-1, CTLA-4, HIFs, LDHA
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