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Proteostasis
Solutions For Complex Protein Networks
Protein homeostasis or ‘proteostasis’ is the process that regulates proteins within the cell in order to maintain the health of both the cellular proteome and the organism itself.
Proteostasis involves a highly complex interconnection of pathways that influence the fate of a protein from synthesis to degradation. As individual components are affected, the others adjust accordingly to maintain normal function. Disruption of one or more of these proteostasis influencers can manifest in pathologies such as Alzheimer’s disease, cancer, and diabetes.
To fuel your proteostatis research, Enzo has an unrivaled portfolio of ubiquitin/proteasome and heat shock protein research solutions. Our development efforts within the areas of protein synthesis, modification, and degradation continue to produce cutting-edge tools for dissecting key biological processes in the proteostasis field. This commitment is evidenced by being first-to-market immunoassays, cell based assays, and compound libraries for autophagy to help researchers better understand cellular regulation of protein turnover and its relation to disease.
Heat Shock Response
The highly conserved heat shock proteins (HSPs) are constitutively expressed and function as molecular chaperones which facilitate the synthesis and folding of proteins. They also participate in protein assembly, export, turn-over, and regulation.
Aggregation & Disaggregation
Detection of protein aggregates has applications in both drug discovery and biotherapeutic production. The formation of aggresomes has been implicated in neurodegenerative and liver disease; therefore, screening for inhibitors has become a primary objective in biopharma. Enzo’s line of PROTEOSTAT® products serve as a toolset for monitoring protein aggregation and stability.
Oxidative Stress Response
The energetic status of mitochondria known as mitochondrial membrane potential, and accumulation of reactive oxygen species (ROS) are frequently assayed as evidence of drug-induced cellular stress. Enzo offers cell based assays for mitochondrial membrane potential and ROS/Superoxide detection, to support our extensive collection of Oxidative Stress products.
Proteasome ELISA kit
Determine 20S proteasome concentration in biological samples with Enzo’s highly cited Proteasome ELISA Kit
Solutions For Autophagy
Comprehensive solutions for the study of autophagy, including ELISA kits, small molecules, live cell analysis Kits and antibodies.
MMP Activity Assays
Our MMP activity assays for screening MMP inhibitors feature ultra-sensitive, long wavelength fluorogenic substrates that reduce interference.