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Toll-like Receptors
High Purity, Validated Ligands and Antibodies
TLRGRADE® LPS & Lipid A Reagents
Providing the purest ligands for identifying pattern recognition receptors (PRRS).
- Ultrapure (≥99.9%)
- Sterile, ready-to-use liquid formulation
- No hazardous handling
- Widely cited in peer-reviewed literature
Worry-Free Antibodies
Enzo offers over 50 TLR antibodies validated for flow cytometry and microscopy applications, backed by our Worry-Free Guarantee.
Key Toll-like Receptor Ligands
| TLR | Ligands |
|---|---|
| TLR 1/2 | Pam3Cys-Ser-(Lys)4. trihydrochloride |
| TLR 2 & TLR 6/2 | MALP-2 |
| TLR 3 | Polyinosinic-polycytidylic acid. potassium salt (TLRgrade® ) (synthetic) |
| TLR 4 | Paclitaxel |
| TLR 5 | Flagellin (high purity) |
| TLR 7/8 | R-848 |
| TLR 9 | ODN 2006 (TLRgrade® ) (synthetic) ODN 1826 (TLRgrade® ) (synthetic) |
High Purity LPS & Lipid A Preparations do not Activate TLR2 or other TLRs
Activation of macrophages from TLR4 wild type compared to TLR4 deficient mice by TLRGRADE® LPS and TLRGRADE® Lipid A from Enzo Life Sciences. Lipid A or LPS concentrations, which induced maximal activation of TLR4 wild type mouse macrophages, were also applied to TLR4 deficient mouse macrophages (105) as follows: 80ng Salmonella LPS (S. minnesota R595 Re), 80ng E. coli LPS (R515 Re), 400ng E. coli Lipid A (R515 Re) and 400ng Salmonella LPS (S. abortus equi S-form). 10 units of IL-6 correspond to the detection limit of the IL-6 ELISA.
