Immunology

Tip The Balance In Your Favor

Comprehensive Tools for Interpreting Immunological Responses

Maintaining the proper balance between immune activation and suppression is critical for physiological functioning of the innate and adaptive immune system. Disruption of this equilibrium leads to immunological disorders including autoimmune diseases, hypersensitivities, and immune deficiency. Enzo provides a comprehensive portfolio of products to detect and modulate the complex processes of immunological disease.

Providing the purest ligands for recognition by pattern recognition receptors.

Optimized Expression Systems Deliver Superior Antigenicity

Highly Virulent Bacterial Toxins

We offer a broad range of native state bacterial and viral antigens for vaccine research and in vitro diagnostics markets. Purified native protein or production in the latest mammalian expression systems ensure that the resultant antigens are expressed to a high level, are in their native folded state, and possess all relevant post-translational modifications.

• High purity
• Reproducible scale-up for bulk quantities
• Lyophilized format for extended shelf-life

Superior Performance From Carefully Engineered TNF Superfamily Ligands

MEGACD40L® (soluble) (human), (recombinant)

• Highly active MEGACD40L® oligomer mimics in vivo membrane-assisted CD40L aggregation and stimulation without the need for enhancers
• High purity with low endotoxin levels
• Experienced manufacturing results in consistent and dependable lot-to-lot
  performance
• Optimized formulation for improved stability and enhanced activity

Enhance Immune Activation with MEGACD40L® Protein

B cell lymphocyte activation by various CD40L constructs. PBMCs were treated for 48 hrs in media containing serially diluted MEGACD40L, CD40L + 2ug/mL Enhancer, or CD40L. Cells were dual-stained with α-human CD19–PE and α -human CD86–APC and analyzed by flow cytometry. Data are presented as the percent of CD19+ B cells that co-stain as CD86+.

Cytokine & Eicosanoid

Cytokines are secreted signaling molecules that mediate and regulate immunity, inflammation and many developmental processes during embryogenesis. Cytokines can have pleiotropic, overlapping, and sometimes contradictory functions, and also play an important role in angiogenesis  and cancer. Eicosanoids are a group of biologically active oxygenated unsaturated fatty acids derived from arachidonic acid by the action of cyclooxygenases, lipoxygenases, and cytochrome P450 mono-oxygenases. The eicosanoid family includes prostaglandins, thromboxanes, leukotrienes, hydroxyeicosatetraenoic acids (HETEs), and lipoxins. Eicosanoids have been shown to enhance, as well as attenuate inflammation and have also been linked to carcinogenesis.

Enzo’s portfolio of ELISA kits for cytokines and eicosanoids features:

• Over 100 sensitive ELISAs for quantifying cytokines and eicosanoids
• Over 20 years of ELISA development and manufacturing experience
• Widely cited in peer-reviewed publications
• Low cost-per-test, high-throughput, multi-plate pack sizes available
• Time-saving, easy-to-use kits with results in less than 3 hours

C-Reactive Protein

C-Reactive Protein (CRP) is a pentraxin family protein that is widely used as a biomarker for systemic inflammation and tissue injury. Its primary role in innate immunity is to function as an opsonin for pathogens via activation of the complement pathway and through binding to Fc gamma receptors. CRP has been shown to play an important role in a variety of pathological pathways.

Enzo offers a broad range of antibodies for use in all areas of immunology. Many are validated for use in key applications such as flow cytometry, immunohistochemistry, immunoprecipitation and Western blotting. Every antibody is backed by our Worry-Free Guarantee, allowing you to evaluate any of our antibodies of interest for your specific application or species without risk.