Caspases

Caspase Activity Assays & Active Enzymes
Caspase-1 Assay Kit for Drug Discovery
- Flexible format allows user to choose between a colorimetric substrate or fluorogenic substrate
- Can be used to screen inhibitors of caspase-1, study enzyme regulation and kinetics, or cleave target substrates
Inhibition of Caspase-1 by Ac-YVAD-CHO

Kinetics of YVAD-pNA cleavage by Caspase-1

Ready-to-Use Caspase Inhibitors
Caspase inhibitors bind to the active site of caspases either in a reversible or irreversible manner. Inhibitors are designed to include a peptide recognition sequence attached to a functional group: an aldehyde (CHO), a chloromethylyketone (CMK), or fluoromethylketone (FMK).
Enzo provide high purity, peptide inhibits for modulation of the caspase signaling cascade.
Broad Spectrum Caspase Inhibitors
Boc-D(OMe)-FMK
Z-VAD(OMe)-FMK
Z-VAD-FMK
Z-VAD-FMK (Ready-to-Use)
Z-Asp-2,6-dichlorobenzoyloxymethylketone
Biotinyl-VAD(OMe)-FMK
Antibody-Based Detection of Cleaved Caspases
Caspase-8 (human) monoclonal antibody (12F5)
- Recognizes procaspase-8 and active caspase-8. Detects procaspase-8 (p55/54), the intermediate cleavage products (p43/41) and the p18 active subunit of caspase-8 by Western blot
- Does not cross-react with mouse caspase-8
- Validated for Western blot, Immunoprecipation and Immunohistochemistry applications
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(B) Detection of Fas ligand-induced caspase-8 processing and activation in human Jurkat cells.