Cell Death

Monitor programmed cell death from membrane to nucleus

Autophagic activity is critical to the maintenance of cellular homeostasis and energy balance. Although typically low under basal conditions, autophagy can be markedly upregulated by a variety of physiological stimuli such as nutrient starvation, hypoxia, endoplasmic reticulum (ER) stress, as well as immune and hormonal stimulation. With our innovative assays and reagents, Enzo enables scientists to gain a deeper understanding of the benefits, and potential consequences, of altering autophagic activity.

Apoptosis (PCD Type 1) is the most-well characterized progammed cell death, band it’s known to be a critical regulator of development, immunity, as well as organ and tissue homeostasis. Apoptotic cells die in a controlled fashion in response to a variety of extrinsic or intrinsic signals (e.g., activation of TNF receptors, DNA damage, mitochondrial pathways). With over 400 products for the analysis of cell death, Enzo enables detection of phenotypic hallmarks of apoptotic cell death.

Necrosis, although not programmed cell death, is the death of cells due to lack of blood flow, caused by an injury, infection, disease, or chemical exposure.