Renin-Angiotensin-Aldosterone System

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The renin-angiotensin–aldosterone system (RAAS) is a critical regulator of blood volume and systemic vascular resistance. It is composed of three major compounds: renin, angiotensin II, and aldosterone.

  • The RAAS functions to elevate blood volume and arterial tone in a prolonged manner. It does this by increasing sodium reabsorption, water reabsorption, and vascular tone.
  • Pharmacologically, the RAAS is a frequently manipulated system in the management of heart failure, hypertension, diabetes mellitus, and acute myocardial infarction.