As a pioneer in nucleic acid labeling and detection technologies, Enzo offers cutting-edge solutions and unparalleled product support tailored to the global academic research, drug discovery, diagnostics, and cell & gene therapy markets. We understand that our customers demand the highest quality reagents to support their research applications, from the precise quantification of nucleic acids vital for gene expression studies and molecular diagnostics to oligo-based therapies requiring high-quality oligos to ensure therapeutic efficacy and safety. That is why we guarantee performance and reliability by manufacturing all of our oligos and reagents to your specifications using rigorous quality control and controlled procedures at our ISO-certified facility.
Explore our custom service options. We support the following requests for catalog and custom oligos and probes:
Small- to large-scale custom synthesis and purification of standard oligos and probes
Customization of oligo sequences, including chemical modifications and labeling
Custom AMPIVIEW® RNA probes for the spatially resolved detection of nucleic acids
Whether you require unique primers and probes to perform a standard PCR reaction or a bulk supply for the development, production, and commercialization of a molecular diagnostic test, we can support you with our custom oligo synthesis services. With decades of experience, our expert team of scientists specializes in the synthesis of oligos with varying sequence complexity, lengths, nucleotide analogs, and a variety of sequence modifications and chemistries for diverse applications, including PCR/RT-PCR, LAMP, genetic diagnostic kits, DNA/RNA sequencing, and ISH. All of our custom oligos are synthesized on our automated systems, with post-synthesis quality assessment via mass spectrometry. Please review our standard packages for custom oligo synthesis.
Certificate of Analysis, MS or HPLC report with Tm
Certificate of Analysis, MS or HPLC report with Tm
Purification
Desalt, HPLC, or cartridge
Desalt, HPLC, or cartridge
Purity
≥ 95% or as requested
≥ 95% or as requested
Format
Lyophilized powder or in solution (i.e., TE buffer or water)
Lyophilized powder or in solution (i.e., TE buffer or water)
* Common modifications include amine, thiol, phosphorylation, biotin, fluorescent dyes, quenchers, etc. ** Turnaround time is subject to change based on probe complexity. Oligo Conjugation
Oligo Conjugation
As a premiere manufacturer of molecular and genomic kits, we take pride in applying our knowledge, proprietary technologies and platforms, manufacturing infrastructure, and quality management systems to accommodate even the most challenging oligo requests. Our oligo conjugation services offer site-specific chemical modification of nucleic acids to support labels, including Enzo’s proprietary dyes (e.g., Red598 and Enzo Gold550), traditional labels and fluorescent dyes (e.g., biotin, Alexa Fluor® fluorescent dyes, etc.), as well as quenchers (e.g., EQ1, EQ2, etc.). Explore our macromolecular labeling solutions, like our patented antibody:oligo conjugate (AOC) technology, to mediate targeted drug delivery, detection, and imaging.
Visualize the expression and spatial biology of nucleic acid targets (DNA and RNA) with AMPIVIEW® RNA probes. Powered by Enzo’s LoopRNA™ ISH technology, AMPIVIEW® RNA probes are uniquely designed with the precision of targeted, sequence-specific RNA probes to deliver superior sensitivity without compromising sample morphology. Our team of scientific experts and manufacturing specialists provides custom probe design, development, and technical support for novel targets in diverse tissue and cell types, ensuring reliable results and saving you time. Combine AMPIVIEW® RNA probes with our in situ hybridization (ISH) services and reach your next discovery faster. Our detection portfolio is optimized across diverse experimental set-ups and protocols, including dual ISH/IHC, offering you dependable options for your research program.
AMPIVIEW® RNA probes
Enabling Your Projects 
GMP Services
Bulk Solutions
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