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PI(3)K-Akt-mTOR Pathway
| Application | Activity assay, Colorimetric detection |
|---|---|
| Species Reactivity | Species independent |
| CAS | 57186-25-1 |
|---|---|
| Couple Type | Blocker, Ligand |
| Purity | ≥97% (HPLC) |
| Alternative Name | PI(3)K p110δ |
|---|---|
| Application | ICC, IHC (PS), WB |
| Host | Rabbit |
| Species Reactivity | Human |
| Alternative Name | 3-(4-(4-Morpholinyl)pyrido[3’,2’:4,5]furo[3,2-d]pyrimidin-2-yl)phenol |
|---|---|
| CAS | 371935-74-9 |
| Couple Type | Inhibitor |
| Purity | ≥97% (HPLC) |
| Alternative Name | Phosphoinositide-3-kinase |
|---|---|
| Application | ICC, IP, WB |
| Host | Mouse |
| Isotype | IgG1 |
| Species Reactivity | Human, Mouse, Rat |
| Alternative Name | PI(3)K p110α/p85α |
|---|---|
| Source | Produced in insect cells. Complex of human full length p110a and p85a subunits of phosphatidylinositol 3-kinase. Produced in a baculovirus expression system. |
| Alternative Name | Phosphatidylinositol 4,5-bisphosphate, PtdIns(4,5)P2 |
|---|---|
| Application | ELISA, ICC |
| Host | Mouse |
| Isotype | IgG2b |
| Species Reactivity | Species independent |
| Alternative Name | Phosphatidylinositol 4,5-bisphosphate, PtdIns(4,5)P2 |
|---|---|
| Application | ELISA, ICC |
| Host | Mouse |
| Isotype | IgG2b |
| Species Reactivity | Species independent |
| Alternative Name | 4'-N-Benzoyl-staurosporine, Midostaurin, CGP 41251 |
|---|---|
| CAS | 120685-11-2 |
| Couple Type | Inhibitor |
| Purity | ≥98% (TLC) |
pp242 . hydrate
ENZ-CHM132
Inhibitor of both mTORC1 and mTORC2. Induces cell death in human and murine leukemia cells.
| Alternative Name | PP-242, 2-[4-Amino-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-1H-indol-5-ol, 2-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-1H-indol-5-ol |
|---|---|
| CAS | 1092351-67-1 |
| Couple Type | Inhibitor |
| Purity | ≥99% (HPLC) |
| Alternative Name | Phosphatase and tensin homolog deleted on chromosome 10 |
|---|---|
| Purity | ≥80% (SDS-PAGE) |
| Source | Produced in E. coli. Full length human PTEN (aa 1-403) is fused at the N-terminus to a His-tag. |
| Alternative Name | Phosphatase and tensin homolog deleted on chromosome 10 |
|---|---|
| Application | ELISA, ICC, IHC, IP, WB |
| Host | Mouse |
| Isotype | IgG2a kappa |
| Species Reactivity | Human, Monkey, Rat |
Rapamycin
BML-A275
An mTOR inhibitor that modulates cell growth, proliferation, and autophagy - frequently used in signaling pathway research and immunosuppressive studies.
| Alternative Name | Sirolimus, AY-22,989, RAPA, Rapamune |
|---|---|
| CAS | 53123-88-9 |
| Couple Type | Inhibitor, Ligand |
| Purity | ≥98% (HPLC) |
| Application | WB |
|---|---|
| Host | Mouse |
| Isotype | IgG1 |
| Species Reactivity | Dog, Human, Mouse, Rat |