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PI(3)K-Akt-mTOR Pathway
| Alternative Name | IP3 receptor type-I, IP3R-I, ITPR1, INSP3R1, IP3R1 |
|---|---|
| Application | ICC, IHC (FS), IP, WB |
| Host | Rabbit |
| Species Reactivity | Dog, Mouse, Rat |
| Alternative Name | IP3R1, ITPR1, IP3R-I, Inositol 1,4,5-triphosphate receptor type 1, INSP3R1 |
|---|---|
| Application | IHC, WB |
| Host | Rabbit |
| Species Reactivity | Dog, Human, Rat |
| Alternative Name | rel-5-[2-[(2R,6S)-2,6-Dimethyl-4-morpholinyl]-4-(4-morpholinyl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxybenzenemethanol, mTOR Inhibitor IV |
|---|---|
| CAS | 938440-64-3 |
| Couple Type | Inhibitor |
| Purity | ≥99% (HPLC) |
| Alternative Name | PtdIns(3,4,5)P3, (1,2-dipalmitoyl)-, 1,2-Dipalmitoyl-sn-glycero-3-phospho-1-D-myo-inositol-3,4,5-trisphosphate . 7Na |
|---|---|
| Couple Type | Substrate |
| Purity | ≥98% (TLC) |
| Couple Type | Activator |
|---|---|
| Purity | ≥98% (NMR) |
| Alternative Name | 2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one |
|---|---|
| CAS | 154447-36-6 |
| Couple Type | Inhibitor |
| Purity | ≥98% (HPLC) |
| Alternative Name | 2-(4-Piperazinyl)-8-phenyl-4H-1-benzopyran-4-one |
|---|---|
| CAS | 154447-38-8 |
| Purity | ≥95% (HPLC) |
| CAS | 1032350-13-2 |
|---|---|
| Couple Type | Inhibitor |
| Purity | ≥99% (HPLC) |
| Alternative Name | 1-(5-Chloronaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine . HCl |
|---|---|
| CAS | 105637-50-1 |
| Couple Type | Inhibitor |
| Purity | ≥98% (TLC) |
| Alternative Name | mTOR (human FKBP12-rapamycin-binding domain) |
|---|---|
| Application | ChIP, ICC, WB |
| Host | Rabbit |
| Species Reactivity | Human |
mTOR inhibitor WYE-132
ENZ-CHM140
Highly potent, ATP-competitive, and specific mTOR kinase inhibitor. Antiproliferative.
| Alternative Name | 1-{4-[1-(1,4-Dioxa-spiro[4.5]dec-8-yl)-4-(8-oxa-3-aza-bicyclo[3.2.1]oct-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]-phenyl}-3-methyl-urea, WYE-125132 |
|---|---|
| CAS | 1144068-46-1 |
| Couple Type | Inhibitor |
| Purity | ≥99% (HPLC) |
mTOR inhibitor WYE-23
ENZ-CHM136
Cell-permeable, potent, selective, and ATP-competitive mTOR inhibitor.
| Alternative Name | 4-{6-[4-(3-Cyclopropyl-ureido)-phenyl]-4-morpholin-4-yl-pyrazolo[3,4-d]pyrimidin-1-yl}-piperidine-1-carboxylic acid methyl ester |
|---|---|
| CAS | 1062169-46-3 |
| Couple Type | Inhibitor |
| Purity | ≥99% (HPLC) |
mTOR inhibitor WYE-28
ENZ-CHM137
Cell-permeable, potent, selective, and ATP-competitive mTOR inhibitor.
| Alternative Name | 4-(6-{4-[3-(4-Hydroxymethyl-phenyl)-ureido]-phenyl}-4-morpholin-4-yl-pyrazolo[3,4-d]pyrimidin-1-yl)-piperidine-1-carboxylic acid methyl ester |
|---|---|
| CAS | 1062172-60-4 |
| Couple Type | Inhibitor |
| Purity | ≥97% (HPLC) |
| Alternative Name | Intelectin-1, Endothelial lectin HL-1, Intestinal lactoferrin receptor, Galactofuranose-binding lectin |
|---|---|
| Purity | ≥95% (SDS-PAGE) |
| Source | Produced in HEK 293 cells. Rat omentin (aa 20-313) is fused at the N-terminus to a FLAG®-tag. |
| Alternative Name | Intelectin-1, Endothelial lectin HL-1, Intestinal lactoferrin receptor, Galactofuranose-binding lectin |
|---|---|
| Purity | ≥95% (SDS-PAGE) |
| Source | Produced in HEK 293 cells. Human omentin 1 (intelectin-1) (aa 17-313) is fused at the N-terminus to a FLAG®-tag. |
| Alternative Name | p70 S6K |
|---|---|
| Source | Produced in insect cells. Active, full length p70 S6K. Produced in a baculovirus expression system. |